About Synvisc-One Hylan G-F 20
In 1997, the FDA approved Synvisc for the treatment of osteoarthritis of the knee. It was first used as a type of Visco-supplementation therapy, which replaced or enhanced the natural synovial fluid in the knee joint. This reduced the discomfort and edema caused by osteoarthritis. Synvisc expanded into its own product line after receiving significant recognition and gaining popularity in the prescription medicine sector. The Synvisc line continued to develop under Sanofi’s ownership, with the introduction of Synvisc One, a single-injection product that offers longer-lasting comfort.
How It Works?
As a single-injection Visco-supplement, SYNVISC-ONE (Hylan G-F 20) helps treat osteoarthritis in the knee by reestablishing the joint’s natural lubrication. It contains cross-linked HA, which improves shock absorption and reduces friction by mimicking the body’s synovial fluid. This improves joint mobility, lowers inflammation, and relieves pain. Long-term relief is provided by SYNVISC-ONE’s prolonged duration of action, which is up to six months. It enables patients to improve their quality of life and regain mobility without the need for regular injections or surgery.
Key Features
- Single Injection Treatment: Synvisc-One is administered as a single injection, offering up to 6 months of pain relief.
- Cross-linked HA: The treatment contains HA, which is cross-linked to increase its viscosity and elasticity, providing better lubrication and shock absorption in the knee joint.
- Long-Lasting Pain Relief: The single injection is stronger than the original formulation, providing extended relief from knee osteoarthritis pain.
Results
- Immediate: Pain and stiffness decrease, improving physical function.
- After 1 to 2 Weeks: A reduction in swelling and discomfort, making movements easier.
- After 4 to 6 Weeks: Full therapeutic effects are felt, completely improving joint function.
Composition
- Hylan A and B
- Glihylan: Derivatives of hyaluronate (sodium salt of HA).
- Disaccharide units of sodium glucuronate and N-acetylglucosamine
- Sodium chloride buffered saline


